Meta-analysis: the efficacy and safety of certolizumab pegol in Crohn’s disease
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15 صفحه اولEfficacy and safety of certolizumab pegol induction therapy in an unselected Crohn's disease population: results of the FACTS survey.
BACKGROUND Switzerland was the first country to approve certolizumab pegol (Cimzia, CZP) for the treatment of patients with moderate to severe Crohn's disease (CD) in September 2007. This phase IV study aimed to evaluate the efficacy and safety of CZP in a Swiss multicenter cohort of practice-based patients. METHODS Baseline and Week 6 evaluation questionnaires were sent to all Swiss gastroen...
متن کاملCertolizumab pegol in the treatment of Crohn's disease.
INTRODUCTION The introduction of antibodies directed against tumour necrosis factor (anti-TNF) has dramatically changed the concept of treating patients with Crohn's disease (CD). Unfortunately, the long-term efficacy of anti-TNF agents may be hampered by immunogenicity. The availability of more anti-TNF agents in the therapeutic armamentarium would therefore be of great benefit in patients loo...
متن کاملPatient Adherence and Efficacy of Certolizumab Pegol in the Management of Crohn’s Disease
Treatment with Anti-Tumor Necrosis Factor (anti-TNF) therapy has become a mainstay of therapy for patients with CD who are unresponsive to conventional medical management. Currently there are three anti-TNFα antibodies that have been approved by the US Food and Drug Administration for the treatment of CD, namely infliximab, adalimumab and certolizumab pegol (CZP). Several double blind placebo c...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2009
ISSN: 0269-2813,1365-2036
DOI: 10.1111/j.1365-2036.2009.03929.x